#3927 AN ANOREXIGENIC HORMONE IN PEDITARIC CKD PATIENTS

Abstract Background and Aims Chronic kidney disease (CKD) is a major health problem associated with faltering growth, which complex process, where anorexia, inadequate oral intake in addition to disturbed body metabolism play significant role. Leptin, the anorexigenic hormone that's secreted by fat tissue, affect appetite, & hence, aids weigh loss growth. The present study evaluated serum leptin level, its relation growth parameters pediatric patients different stages of CKD. Method A cross-sectional that was conducted on 87 subjects, who were divided equally into groups; CKD stage 5 regular hemodialysis (CKD5d), 2–4, age gender matched controls. Patient diabetes, infected hepatitis C virus, therapies excluded. Full history taking, assessment using specific Z-scores heights, weight mass index done. Fasting leptin, calcium, phosphorus, PTH, albumin, total proteins, iron hemoglobin measured. Results Our had significantly lower compared Hypocalcemia, high deficiency anemia hypoalbuminemia CKD2-4 groups other groups. Serum abnormally 12.6% patients. median level comparable between (p = 0.20). hadn’t changed as regards gender, BMI Z-scores, diagnoses, or 1.00, 0.379, 0.542, 0.171 respectively). negative correlation found duration (r -0.276, P 0.036), otherwise, no correlations clinical laboratory variables. Conclusion Leptin not affected useful marker for Large studies relationship needed.